Multiple cutaneous reticulohistiocytosis with T-cell large granular lymphocyte clonopathy.

A 63-year-old Caucasian man presented with a 4-month history of disseminated asymptomatic reddish-brown papulonodular lesions. A skin biopsy showed dermal infiltration with CD68+ histiocytes, predominantly with eosinophilic cytoplasm, some with a ground-glass cytoplasm, and a small number of giant cells. The diagnosis of multiple cutaneous reticulohistiocytosis was made. Bone marrow immunophenotyping due to peripheral blood lymphocytosis revealed the presence of a monoclonal population of CD3+ , CD8+ CD57+ large granular lymphocytes. The present case suggests the coexistence of multiple cutaneous reticulohistiocytosis with an underlying disorder.

Multiple Cutaneous Reticulohistiocytoma.

Multicentric reticulohistiocytosis is a rare non-Langerhans cell histiocytosis characterized in its full form by severe destructive arthritis, cutaneous nodules, and systemic manifestations. Cutaneous lesions may precede, accompany, or more commonly develop later than other features in this disease. We describe a case of multiple cutaneous reticulohistiocytoma without any systemic associations after thorough investigations.

A Case of Multiple Cutaneous Reticulohistiocytosis / 대한피부과학회지

Mutiple cutaneous reticulohistiocytosis represent a unique pattern in the spectrum of reticulohistiocytoses, and are characterized by multiple granulomas confined to the skin without evidence of arthritis or underlying systemic illness. We report a case of multiple cutaneous reticulohistiocytosis in a 31-year-old male, who presented with multiple, asymptomatic reddish-brown or skin-colored papules on the whole body. Histopathologically, there were numerous mononuclear and multinucleated histiocytes with a ground glass appearance in the dermis. The histiocytes were diastase-resistant, and periodic acid-Schiff reagent and CD 68 positive. The patient was treated with narrow band UVB for 1 month and slightly improved slightly.